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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Free Radic Biol Med. 2015 Aug 5;88(Pt B):290–301. doi: 10.1016/j.freeradbiomed.2015.06.008

Fig. 3.

Fig. 3

Complexity of SKN-1 functions. SKN-1 directly or indirectly controls genes involved in a wide variety of biological processes (blue arrows), overlapping subsets of which may be up-regulated by different stresses. SKN-1 is activated by stress signals (black arrows) and senses the activity of multiple cellular processes, some of which are shown here in red. TEF and TIF refer to translation elongation and initiation, disruption of which appears to activate SKN-1 through different mechanisms [50,78].