Table.

Mitochondrial Respiratory Inhibitors That Have Been Shown to Protect the Heart or Brain From Ischemia/Reperfusion Injury, and Their Sites of Action

Site of Action	Inhibitor	References
Complex I	Rotenone	Lesnefsky et al31
	Amobarbital	Stewart et al53
	S-nitrosothiols	Nadtochiy et al,54 Prime et al,55 Burwell et al,56 and Nadtochiy et al57
	Nitrite	Shiva et al58 and Dezfulian et al59
	Metformin	Owen et al,60 Legtenberg et al,61 Bhamra et al,62 and Matsuzaki et al63
	Capsaicin	D’Alonzo et al64 and Satoh et al65
	Isoflurane	Hanley et al66 and Cope et al67
	Ranolazine	Wyatt et al68
Complex II	Atpenin A5	Wojtovich et al69
	Diazoxide	Anastacio et al70 and Wang et al71
	Malonate	Chouchani et al,14 Boylston et al,72 and Wojtovich et al73
	Nitroxyl	Pagliaro et al74 and Shiva et al75
	3-Nitropropionate	Riepe et al76
	Nitro-alkenes	Nadtochiy et al77
Complex III	Antimycin A	Kabir et al78
Complex IV	Nitric oxide	Zhao et al79
	Carbon monoxide	Clark et al80
	Hydrogen sulfide	Khan et al,81 Pan et al,82 and Elrod et al83

Note: Some references are paired such that the phenomenon of a molecule inhibiting a respiratory complex and the phenomenon of it being protective in ischemia/reperfusion injury are not necessarily co-observed in the same experimental system. Inclusion of a molecule in this table should not be misconstrued as claiming that the mechanism of its protection is dependent on its effects on a given respiratory complex.