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Published in final edited form as: J Immunol. 2008 Dec 15;181(12):8478–8484. doi: 10.4049/jimmunol.181.12.8478

TLR11-deficient mice develop acute pancreatitis in response to T. gondii infection. A, Development of fat necrosis in T. gondii-infected TLR11^−/− mice. WT, TLR11^−/−, MyD88^−/−, or Caspase1^−/− were infected with an average of 20 cysts per mouse of the ME49 strain of T. gondii and the peritoneal cavities were examined 5 days later. B, Animals were infected as described above and pancreatic tissues were removed for histological analysis (H&E staining). The images shown are representative of multiple sections examined in three or four mice per group. C, WT, TLR11^−/−, MyD88^−/−, or Caspase1^−/− were infected as described above and 5 days later serum levels of amylase were analyzed; □, T. gondii infected; , naive controls. The data are representative of eight experiments performed. D, Serum levels of inflammation marker alanine amino-transferase (ALT) in mice infected with T. gondii. The data are representative of three experiments performed.

Inline graphic — TLR11-deficient mice develop acute pancreatitis in response to T. gondii infection. A, Development of fat necrosis in T. gondii-infected TLR11^−/− mice. WT, TLR11^−/−, MyD88^−/−, or Caspase1^−/− were infected with an average of 20 cysts per mouse of the ME49 strain of T. gondii and the peritoneal cavities were examined 5 days later. B, Animals were infected as described above and pancreatic tissues were removed for histological analysis (H&E staining). The images shown are representative of multiple sections examined in three or four mice per group. C, WT, TLR11^−/−, MyD88^−/−, or Caspase1^−/− were infected as described above and 5 days later serum levels of amylase were analyzed; □, T. gondii infected; , naive controls. The data are representative of eight experiments performed. D, Serum levels of inflammation marker alanine amino-transferase (ALT) in mice infected with T. gondii. The data are representative of three experiments performed.