Fig. 4.

Modeling of synaptic events. (A) Synaptic events were simulated according to Model 1 and the rate constants given in Table 2. Receptor activation was driven by a 1 millisecond-long square-pulse of 10 mM GABA (arrow) in the absence (control) and presence of saturating concentrations of e18,19dinor3α5α16O, 3α5α17βEt, or e3α5α4βOMe16O. Overlaid on the data traces are single-exponential fits that yielded 18 milliseconds, 37 milliseconds, 66 milliseconds, and 112 milliseconds for control, e18,19dinor3α5α16O, 3α5α17βEt, or e3α5α4βOMe16O, respectively. (B) The fitted lines from (A) are overlaid on the averaged sIPSCs obtained under control conditions (no steroid), and in the presence of e18,19dinor3α5α16O, 3α5α17βEt, or e3α5α4βOMe16O.