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Dose-effect functions for Δ9-THC (A), methanandamide (B), URB597 (C), and anandamide alone (open inverted-triangle) or following treatment of 3.2mg/kg URB597 (filled inverted-triangle) (D) on progressive ratio. Abscissae, cumulative dose, log scale; ordinate, mean change in breakpoint. Points represent averages (±S.E.M.) for the groups of subjects. A larger dose of Δ9-THC (1.0 mg/kg) was tested, but performance was abolished making breakpoints indeterminate; n = 6.
