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COX-1 inhibition profiles of DCF, OH-DCF, and DCF-AG. Recombinant COX-1 was incubated in the presence of inhibitors for 2 minutes at 37°C, and the formation of PGE2 from AA was monitored via LC–MS/MS. Data reflect the mean ± standard error of the mean from three separate studies (n = 2 replicates per study). Inhibition data were fit with a three-parameter model to calculate IC50. Dotted lines reflect the 95% confidence intervals of the fit.
