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Discriminative stimulus and response rate effects of fentanyl in fentanyl-trained animals (A) and drug substitution studies with Ro-64-6198 (B). Data from individual monkeys (BC, MT, and BU) and their mean (± S.E.M.) are plotted (n = 3). All animals were trained to discriminate fentanyl 0.01 mg/kg. Abscissae: dose in milligrams per kilogram, and vehicle responding (V). Ordinates: percent fentanyl-lever responding and response rate (responses/s).
