TABLE 1.
Chemical structures of neurosteroids tested for extrasynaptic activity
| Steroid | C3 Position (R1) | C5 Position (R2) | C17 Position (R3) | Key Structural Significance |
|---|---|---|---|---|
| 3α 5α-AP | α-OH | α-H | -COCH3 | 3α-hydroxyl, 5α-reduction,17-acetyl |
| GX | α-OH β-CH3 | α-H | -COCH3 | 3β-methyl |
| 3α 5β-AP | α-OH | β-H | -COCH3 | 5β-reduction |
| 3β5α -AP | β-OH | α-H | -COCH3 | 3β-hydroxyl |
| THDOC | α-OH | α-H | -COCH2OH | 21-hydroxyl |
| ALFX | α-OH | α-H | -COCH3 | 11-carbonyl |
| AD | α-OH | α-H | β-OH | 17-hydroxyl |
| AN | α-OH | α-H | =O | 17-carbonyl |
| ETIO | α-OH | β-H | =O | 17-carbonyl, 5β-reduction |
| ORG-20599 | α-H | α-H | -COCH2Cl | 2β-(4-morpholinyl), 17-acyl chloride |