Table S1.
ID | Sex | Age-group, years | COPD diagnosis | Emph | PaO2, range | PaCO2, range | Cancer | Stage | Time | D |
---|---|---|---|---|---|---|---|---|---|---|
1 | F | 30–74 | No COPD | 0 | 10–15 | 3–4.9 | Ad-NSCLC | III | 377 | 1 |
2 | M | 30–74 | Missing – spirometry | 0 | NA | NA | SCC – NSCLC | IV | 340 | 1 |
3 | M | 30–74 | No COPD | 1 | 10–15 | 3–4.9 | SCLC | IV | 157 | 1 |
4 | M | 30–74 | No COPD | 0 | 10–15 | 3–4.9 | SCLC | IV | 547 | 1 |
5 | M | 30–74 | No COPD | 0 | 10–15 | 5–5.9 | Ad-NSCLC | IV | 2,067 | 1 |
6 | M | 30–74 | No COPD | 0 | 10–15 | 5–5.9 | SCC – NSCLC | III | 1,243 | 1 |
7 | M | 30–74 | No COPD | 0 | 10–15 | 3–4.9 | SCC – NSCLC | III | 279 | 1 |
8 | M | 30–74 | Known COPD | 1 | 4–8.4 | 5–5.9 | SCLC | III | 365 | 1 |
9 | F | 75–91 | Known COPD | 0 | 10–15 | 5–5.9 | SCLC | III | 620 | 1 |
10 | M | 75–91 | Known COPD | 0 | 8.5–9.9 | 3–4.9 | SCLC | IV | 16 | 1 |
11 | F | 30–74 | No COPD | 0 | 10–15 | 3–4.9 | Other – NSCLC | I | 803 | 1 |
12 | M | 75–91 | No COPD | 1 | 4–8.4 | 5–5.9 | SCLC | IV | 77 | 1 |
13 | F | 30–74 | No COPD | 0 | 10–15 | 5–5.9 | Ad-NSCLC | I | 353 | 1 |
14 | M | 30–74 | No COPD | 1 | 10–15 | 3–4.9 | SCLC | IV | 188 | 1 |
15 | M | 30–74 | No COPD | 0 | 10–15 | 5–5.9 | SCC – NSCLC | II | 289 | 1 |
16 | F | 30–74 | No COPD | 1 | 4–8.4 | 6–10 | SCC – NSCLC | III | 2,175 | 1 |
17 | M | 30–74 | Missing – spirometry | 0 | 10–15 | 5–5.9 | SCC – NSCLC | IV | 104 | 1 |
18 | M | 75–91 | Missing – spirometry | 1 | 4–8.4 | 3–4.9 | NA | IV | 10 | 1 |
19 | M | 30–74 | No COPD | 0 | 10–15 | 3–4.9 | Other – NSCLC | IV | 41 | 1 |
20 | M | 30–74 | No COPD | 0 | 10–15 | 3–4.9 | SCLC | NA | 155 | 1 |
21 | F | 30–74 | No COPD | 0 | 8.5–9.9 | 5–5.9 | Ad-NSCLC | IV | 245 | 1 |
22 | M | 30–74 | No COPD | 0 | 10–15 | 5–5.9 | SCC – NSCLC | IV | 116 | 1 |
23 | F | 30–74 | No COPD | 1 | 10–15 | 3–4.9 | Ad-NSCLC | IV | 131 | 1 |
24 | M | 30–74 | Known COPD | 1 | 4–8.4 | 3–4.9 | Ad-NSCLC | IV | 287 | 1 |
25 | M | 75–91 | No COPD | 1 | 10–15 | 5–5.9 | SCC – NSCLC | IV | 45 | 1 |
26 | F | 30–74 | No COPD | 0 | 10–15 | 3–4.9 | Ad-NSCLC | III | 1,787 | 1 |
27 | M | 75–91 | Undiagnosed COPD | 1 | 8.5–9.9 | 5–5.9 | SCC – NSCLC | IV | 52 | 1 |
28 | F | 30–74 | Missing – spirometry | 1 | 4–8.4 | 5–5.9 | SCC – NSCLC | IV | 54 | 1 |
29 | M | 30–74 | No COPD | 0 | 10–15 | 3–4.9 | NA | IV | 162 | 1 |
30 | M | 75–91 | Known COPD | 1 | 4–8.4 | 6–10 | SCC – NSCLC | IV | 319 | 1 |
31 | F | 30–74 | No COPD | 0 | 10–15 | 3–4.9 | Ad-NSCLC | IV | 561 | 1 |
32 | M | 30–74 | Known COPD | 1 | 4–8.4 | 5–5.9 | SCLC | IV | 1,076 | 1 |
33 | M | 30–74 | Missing – spirometry | 1 | NA | NA | SCC – NSCLC | III | 91 | 1 |
34 | M | 75–91 | Known COPD | 0 | 10–15 | 5–5.9 | SCLC | III | 27 | 1 |
35 | M | 75–91 | No COPD | 0 | 10–15 | 3–4.9 | SCLC | IV | 7 | 1 |
36 | F | 30–74 | No COPD | 0 | 4–8.4 | 5–5.9 | Ad-NSCLC | IV | 76 | 1 |
37 | F | 75–91 | No COPD | 0 | 10–15 | 3–4.9 | Ad-NSCLC | II | 192 | 1 |
38 | F | 75–91 | No COPD | 1 | 10–15 | 3–4.9 | SCC – NSCLC | II | 370 | 1 |
39 | F | 30–74 | No COPD | 1 | 8.5–9.9 | 6–10 | Ad-NSCLC | I | 377 | 1 |
40 | M | 75–91 | Missing – spirometry | 0 | 10–15 | 5–5.9 | SCC – NSCLC | IV | 36 | 1 |
41 | F | 30–74 | Known COPD | 0 | 10–15 | 5–5.9 | Other – NSCLC | III | 33 | 1 |
42 | M | 30–74 | Known COPD | 0 | 4–8.4 | 5–5.9 | SCLC | III | 1,461 | 1 |
43 | M | 30–74 | No COPD | 1 | 10–15 | 3–4.9 | Other – NSCLC | IV | 141 | 1 |
44 | F | 30–74 | Missing – spirometry | 1 | NA | NA | SCC – NSCLC | III | 28 | 1 |
45 | F | 30–74 | No COPD | 0 | 8.5–9.9 | 5–5.9 | Ad-NSCLC | IV | 576 | 1 |
46 | F | 30–74 | Missing – spirometry | 1 | 4–8.4 | 5–5.9 | SCLC | IV | 130 | 1 |
47 | M | 30–74 | Known COPD | 1 | 4–8.4 | 5–5.9 | Ad-NSCLC | III | 38 | 1 |
48 | F | 75–91 | No COPD | 1 | 10–15 | 3–4.9 | Ad-NSCLC | IV | 44 | 1 |
49 | M | 30–74 | No COPD | 1 | 10–15 | 5–5.9 | Ad-NSCLC | I | 2,298 | 0 |
50 | M | 30–74 | No COPD | 0 | 10–15 | 6–10 | Ad-NSCLC | III | 132 | 1 |
51 | M | 30–74 | Undiagnosed COPD | 1 | 8.5–9.9 | 5–5.9 | Ad-NSCLC | III | 83 | 1 |
52 | M | 30–74 | No COPD | 1 | 10–15 | 3–4.9 | Ad-NSCLC | III | 204 | 1 |
53 | M | 30–74 | No COPD | 1 | 8.5–9.9 | 5–5.9 | SCLC | IV | 166 | 1 |
54 | F | 75–91 | Undiagnosed COPD | 0 | 8.5–9.9 | 6–10 | SCC – NSCLC | II | 50 | 1 |
55 | F | 30–74 | No COPD | 0 | 10–15 | 5–5.9 | SCLC | IV | 175 | 1 |
56 | M | 75–91 | No COPD | 1 | 8.5–9.9 | 3–4.9 | SCC – NSCLC | III | 28 | 1 |
57 | M | 30–74 | Undiagnosed COPD | 1 | 10–15 | 5–5.9 | SCC – NSCLC | I | 2,155 | 1 |
58 | M | 30–74 | Known COPD | 0 | 10–15 | 3–4.9 | Other – NSCLC | IV | 168 | 1 |
59 | F | 30–74 | Missing – spirometry | 0 | 4–8.4 | 3–4.9 | Ad-NSCLC | IV | 2 | 1 |
60 | M | 75–91 | Known COPD | 0 | 10–15 | 5–5.9 | SCC – NSCLC | III | 415 | 1 |
61 | M | 30–74 | No COPD | 0 | 10–15 | 5–5.9 | Ad-NSCLC | IV | 917 | 1 |
62 | M | 30–74 | Known COPD | 1 | 10–15 | 5–5.9 | SCC – NSCLC | III | 475 | 1 |
63 | F | 30–74 | No COPD | 0 | 8.5–9.9 | 5–5.9 | SCLC | IV | 1,485 | 1 |
64 | M | 30–74 | Known COPD | 1 | 4–8.4 | 3–4.9 | SCLC | III | 13 | 1 |
65 | M | 75–91 | Undiagnosed COPD | 1 | 8.5–9.9 | 3–4.9 | SCC – NSCLC | III | 460 | 1 |
66 | F | 30–74 | No COPD | 0 | NA | NA | Ad-NSCLC | III | 698 | 1 |
67 | M | 30–74 | Known COPD | 1 | 4–8.4 | 5–5.9 | Ad-NSCLC | IV | 226 | 1 |
68 | M | 30–74 | No COPD | 0 | 8.5–9.9 | 5–5.9 | Ad-NSCLC | IV | 184 | 1 |
69 | F | 30–74 | No COPD | 1 | 10–15 | 5–5.9 | Ad-NSCLC | I | 2,196 | 0 |
70 | F | 30–74 | No COPD | 0 | 10–15 | 5–5.9 | Ad-NSCLC | III | 265 | 1 |
71 | F | 30–74 | No COPD | 1 | 8.5–9.9 | 3–4.9 | SCC – NSCLC | II | 2,189 | 0 |
72 | M | 30–74 | No COPD | 1 | 10–15 | 3–4.9 | SCC – NSCLC | III | 287 | 1 |
73 | M | 30–74 | Known COPD | 1 | 8.5–9.9 | 5–5.9 | SCLC | IV | 492 | 1 |
74 | M | 30–74 | Missing – spirometry | 0 | 8.5–9.9 | 6–10 | SCC – NSCLC | IV | 501 | 1 |
75 | F | 30–74 | No COPD | 0 | 8.5–9.9 | 5–5.9 | Ad-NSCLC | II | 1,758 | 1 |
76 | M | 30–74 | No COPD | 0 | 10–15 | 5–5.9 | SCC – NSCLC | III | 432 | 1 |
77 | F | 30–74 | No COPD | 0 | 10–15 | 5–5.9 | SCLC | III | 2,142 | 0 |
78 | M | 30–74 | No COPD | 1 | NA | NA | SCC – NSCLC | II | 2,141 | 0 |
79 | M | 30–74 | No COPD | 1 | 8.5–9.9 | 3–4.9 | SCLC | IV | 18 | 1 |
80 | F | 30–74 | Missing – spirometry | 0 | 10–15 | 3–4.9 | SCLC | IV | 19 | 1 |
81 | M | 75–91 | Missing – spirometry | 0 | NA | NA | SCLC | IV | 35 | 1 |
82 | F | 30–74 | Missing – spirometry | 0 | 8.5–9.9 | 3–4.9 | SCC – NSCLC | IV | 135 | 1 |
83 | F | 30–74 | Known COPD | 1 | 4–8.4 | 3–4.9 | SCLC | IV | 111 | 1 |
84 | F | 30–74 | Known COPD | 0 | NA | NA | SCLC | IV | 58 | 1 |
85 | F | 30–74 | Undiagnosed COPD | 1 | 10–15 | 5–5.9 | SCC – NSCLC | III | 2,114 | 0 |
86 | F | 30–74 | No COPD | 0 | NA | NA | Ad-NSCLC | III | 254 | 1 |
87 | M | 75–91 | Missing – spirometry | 1 | NA | NA | SCLC | IV | 35 | 1 |
88 | F | 75–91 | No COPD | 0 | 4–8.4 | 3–4.9 | Ad-NSCLC | IV | 18 | 1 |
89 | M | 75–91 | Known COPD | 1 | 10–15 | 3–4.9 | SCLC | II | 417 | 1 |
90 | M | 30–74 | Known COPD | 1 | 10–15 | 5–5.9 | Ad-NSCLC | I | 249 | 1 |
91 | F | 30–74 | Known COPD | 1 | 4–8.4 | 6–10 | Ad-NSCLC | III | 630 | 1 |
92 | F | 30–74 | Undiagnosed COPD | 0 | 10–15 | 3–4.9 | Ad-NSCLC | IV | 22 | 1 |
93 | M | 30–74 | No COPD | 1 | 10–15 | 5–5.9 | Ad-NSCLC | III | 728 | 1 |
94 | M | 75–91 | No COPD | 1 | 8.5–9.9 | 3–4.9 | NA | III | 171 | 1 |
95 | F | 30–74 | Known COPD | 0 | 8.5–9.9 | 5–5.9 | SCLC | IV | 512 | 1 |
96 | F | 30–74 | Missing – spirometry | 1 | NA | NA | Ad-NSCLC | IV | 455 | 1 |
97 | M | 30–74 | Known COPD | 0 | 10–15 | 5–5.9 | SCLC | III | 441 | 1 |
98 | F | 75–91 | Known COPD | 1 | 4–8.4 | 5–5.9 | SCC – NSCLC | I | 1,329 | 1 |
99 | M | 75–91 | Known COPD | 1 | 4–8.4 | 3–4.9 | SCC – NSCLC | III | 163 | 1 |
100 | F | 30–74 | No COPD | 0 | 10–15 | 3–4.9 | SCLC | I | 1,902 | 0 |
101 | F | 75–91 | No COPD | 0 | 10–15 | 3–4.9 | Ad-NSCLC | IV | 537 | 1 |
102 | F | 75–91 | No COPD | 0 | 8.5–9.9 | 5–5.9 | NA | IV | 345 | 1 |
103 | F | 75–91 | Undiagnosed COPD | 0 | 4–8.4 | 5–5.9 | Ad-NSCLC | IV | 159 | 1 |
104 | M | 75–91 | Missing – spirometry | 0 | NA | NA | NA | IV | 14 | 1 |
105 | M | 30–74 | No COPD | 0 | 8.5–9.9 | 5–5.9 | SCLC | I | 1,983 | 0 |
106 | M | 75–91 | Known COPD | 1 | 8.5–9.9 | 5–5.9 | SCC – NSCLC | II | 526 | 1 |
107 | M | 30–74 | Missing – spirometry | 1 | NA | NA | Ad-NSCLC | IV | 222 | 1 |
108 | F | 75–91 | Known COPD | 1 | NA | NA | Ad-NSCLC | IV | 82 | 1 |
109 | M | 75–91 | Known COPD | 0 | 8.5–9.9 | 5–5.9 | Ad-NSCLC | IV | 168 | 1 |
110 | F | 75–91 | Known COPD | 1 | 4–8.4 | 5–5.9 | SCC – NSCLC | III | 197 | 1 |
111 | M | 30–74 | No COPD | 0 | NA | NA | Ad-NSCLC | IV | 1,412 | 1 |
112 | F | 30–74 | No COPD | 0 | 10–15 | 5–5.9 | SCC – NSCLC | IV | 1,092 | 1 |
113 | M | 75–91 | No COPD | 1 | 8.5–9.9 | 3–4.9 | SCC – NSCLC | II | 195 | 1 |
114 | M | 30–74 | Known COPD | 1 | 10–15 | 5–5.9 | SCLC | IV | 990 | 1 |
115 | F | 75–91 | No COPD | 1 | 10–15 | 5–5.9 | Ad-NSCLC | I | 1,254 | 1 |
116 | M | 30–74 | No COPD | 1 | 8.5–9.9 | 3–4.9 | SCC – NSCLC | III | 789 | 1 |
117 | F | 30–74 | Undiagnosed COPD | 1 | 10–15 | 5–5.9 | Ad-NSCLC | II | 1,892 | 0 |
118 | F | 75–91 | Known COPD | 1 | 8.5–9.9 | 3–4.9 | SCLC | I | 921 | 1 |
119 | F | 30–74 | Known COPD | 1 | 4–8.4 | 5–5.9 | SCC – NSCLC | III | 618 | 1 |
120 | M | 30–74 | Undiagnosed COPD | 0 | 10–15 | 5–5.9 | SCLC | I | 1,875 | 0 |
121 | F | 30–74 | Known COPD | 1 | 8.5–9.9 | 3–4.9 | SCC – NSCLC | III | 69 | 1 |
122 | M | 30–74 | Undiagnosed COPD | 1 | 4–8.4 | 3–4.9 | Ad-NSCLC | IV | 16 | 1 |
123 | F | 30–74 | No COPD | 1 | 10–15 | 3–4.9 | Ad-NSCLC | IV | 181 | 1 |
124 | M | 75–91 | Known COPD | 1 | 10–15 | 3–4.9 | SCC – NSCLC | IV | 81 | 1 |
125 | M | 30–74 | Known COPD | 1 | 10–15 | 3–4.9 | Ad-NSCLC | III | 195 | 1 |
126 | M | 30–74 | No COPD | 1 | 10–15 | 3–4.9 | SCC – NSCLC | III | 471 | 1 |
127 | F | 30–74 | Known COPD | 1 | 8.5–9.9 | 6–10 | SCC – NSCLC | III | 92 | 1 |
128 | M | 30–74 | No COPD | 1 | 8.5–9.9 | 3–4.9 | SCLC | IV | 3 | 1 |
129 | M | 30–74 | No COPD | 1 | 8.5–9.9 | 5–5.9 | SCC – NSCLC | IV | 153 | 1 |
130 | M | 30–74 | Known COPD | 1 | 10–15 | 6–10 | SCC – NSCLC | I | 555 | 1 |
131 | M | 30–74 | Known COPD | 1 | 10–15 | 3–4.9 | Ad-NSCLC | III | 148 | 1 |
132 | M | 75–91 | No COPD | 1 | NA | NA | Ad-NSCLC | I | 1,847 | 0 |
133 | M | 30–74 | Known COPD | 1 | 10–15 | 5–5.9 | SCC – NSCLC | III | 417 | 1 |
134 | M | 30–74 | No COPD | 1 | 10–15 | 5–5.9 | SCC – NSCLC | I | 1,840 | 0 |
135 | M | 30–74 | No COPD | 1 | 10–15 | 5–5.9 | SCC – NSCLC | II | 1,875 | 0 |
136 | F | 30–74 | No COPD | 1 | NA | NA | Ad-NSCLC | III | 776 | 1 |
137 | M | 30–74 | No COPD | 1 | 4–8.4 | 3–4.9 | Ad-NSCLC | IV | 14 | 1 |
138 | F | 30–74 | Undiagnosed COPD | 1 | 10–15 | 3–4.9 | SCLC | IV | 437 | 1 |
139 | F | 30–74 | Known COPD | 1 | 10–15 | 3–4.9 | Ad-NSCLC | III | 1,818 | 0 |
140 | M | 75–91 | No COPD | 1 | 8.5–9.9 | 5–5.9 | SCLC | III | 924 | 1 |
141 | M | 75–91 | Known COPD | 1 | 10–15 | 5–5.9 | SCC – NSCLC | I | 1,797 | 0 |
142 | M | 30–74 | Known COPD | 0 | 8.5–9.9 | 3–4.9 | SCC – NSCLC | IV | 214 | 1 |
143 | F | 30–74 | Known COPD | 1 | 8.5–9.9 | 5–5.9 | SCC – NSCLC | I | 1,744 | 0 |
144 | M | 75–91 | Missing – spirometry | 1 | 8.5–9.9 | 5–5.9 | SCC – NSCLC | III | 701 | 1 |
145 | M | 30–74 | No COPD | 0 | 10–15 | 3–4.9 | Ad-NSCLC | IV | 278 | 1 |
146 | M | 75–91 | Known COPD | 1 | 10–15 | 3–4.9 | Ad-NSCLC | IV | 397 | 1 |
147 | M | 30–74 | No COPD | 1 | 10–15 | 5–5.9 | SCLC | III | 176 | 1 |
148 | M | 30–74 | Missing – spirometry | 1 | 4–8.4 | 5–5.9 | Ad-NSCLC | IV | 37 | 1 |
149 | M | 30–74 | Known COPD | 0 | 10–15 | 5–5.9 | Ad-NSCLC | IV | 290 | 1 |
150 | F | 30–74 | Known COPD | 1 | 8.5–9.9 | 5–5.9 | NA | III | 249 | 1 |
151 | M | 30–74 | Missing – spirometry | 1 | NA | NA | Ad-NSCLC | IV | 131 | 1 |
152 | F | 30–74 | No COPD | 1 | NA | NA | SCLC | IV | 288 | 1 |
153 | M | 75–91 | Known COPD | 1 | 10–15 | 6–10 | SCC – NSCLC | I | 98 | 1 |
154 | F | 30–74 | No COPD | 0 | 10–15 | 5–5.9 | Ad-NSCLC | III | 1,747 | 0 |
155 | M | 30–74 | Known COPD | 1 | 8.5–9.9 | 5–5.9 | SCC – NSCLC | III | 741 | 1 |
156 | M | 75–91 | Missing – spirometry | 1 | NA | NA | SCLC | IV | 184 | 1 |
157 | F | 30–74 | No COPD | 1 | 8.5–9.9 | 5–5.9 | SCLC | IV | 398 | 1 |
158 | M | 30–74 | No COPD | 0 | 10–15 | 5–5.9 | SCLC | IV | 449 | 1 |
159 | M | 30–74 | No COPD | 0 | 10–15 | 3–4.9 | Ad-NSCLC | II | 1,437 | 1 |
160 | F | 30–74 | No COPD | 0 | 10–15 | 3–4.9 | Ad-NSCLC | IV | 166 | 1 |
161 | M | 30–74 | No COPD | 1 | 8.5–9.9 | 3–4.9 | Ad-NSCLC | IV | 141 | 1 |
162 | M | 30–74 | No COPD | 0 | 10–15 | 3–4.9 | SCC – NSCLC | III | 1,001 | 1 |
163 | F | 30–74 | Missing – spirometry | 1 | 10–15 | 5–5.9 | SCLC | IV | 181 | 1 |
164 | F | 75–91 | Known COPD | 1 | 10–15 | 5–5.9 | Ad-NSCLC | II | 335 | 1 |
165 | F | 30–74 | Missing – spirometry | 0 | NA | NA | SCC – NSCLC | IV | 236 | 1 |
166 | F | 75–91 | Known COPD | 1 | 8.5–9.9 | 5–5.9 | Other – NSCLC | IV | 68 | 1 |
167 | M | 30–74 | Known COPD | 1 | 8.5–9.9 | 6–10 | Ad-NSCLC | IV | 9 | 1 |
168 | M | 30–74 | Known COPD | 1 | 4–8.4 | 5–5.9 | SCLC | I | 445 | 1 |
169 | F | 30–74 | No COPD | 0 | NA | NA | SCLC | III | 514 | 1 |
170 | F | 30–74 | Known COPD | 0 | NA | NA | SCLC | IV | 333 | 1 |
171 | F | 30–74 | Known COPD | 1 | 10–15 | 3–4.9 | Ad-NSCLC | II | 243 | 1 |
172 | F | 30–74 | Known COPD | 1 | 4–8.4 | 5–5.9 | SCLC | IV | 244 | 1 |
173 | F | 30–74 | No COPD | 1 | 10–15 | 5–5.9 | SCC – NSCLC | III | 632 | 1 |
174 | M | 30–74 | Missing – spirometry | 1 | NA | NA | Ad-NSCLC | IV | 57 | 1 |
Notes: Time represents survival time (days) from diagnosis of primary lung cancer; D represents a censoring variable (1 if dead, 0 if alive at the end of the study period); PaO2 and PaCO2 in kPa. Patients with missing data were categorized as “missing – spirometry”.
Abbreviations: Ad-NSCLC, adenocarcinoma non-small-cell lung cancer; Emph, emphysema; F, female; M, male; NA, not available; PaO2, partial arterial oxygen pressure; SCC, squamous cell carcinoma; SCLC, small-cell lung cancer; PaCO2, partial arterial carbon dioxide pressure.