Figure 2. Lovastatin treatment reduces mortality associated with GVHD.
Mice were treated with statins at the dose of 50 μg/mouse every other day, starting on the same day as the BMT. The control group received vehicle (10% DMSO in saline). Survival was monitored daily and followed up until 28 days. The data was the combination of all the mice examined. Distributions of time to death were estimated using the Kaplan-Meier method and compared between treatments by using the log-rank Test. No adjustment was made for the comparisons. Results were from at least three independent experiments with 3 mice per group in each experiment.
