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. Author manuscript; available in PMC: 2016 Mar 28.
Published in final edited form as: Biol Blood Marrow Transplant. 2009 Oct 7;15(12):1513–1522. doi: 10.1016/j.bbmt.2009.08.013

Figure 3. Lovastatin treatment Reduces GVHD in skin and liver.

Figure 3

Mice were sacrificed on day 7 post-transplant (4 mice per group). Tissues were placed in 10% formalin, embedded in paraffin, sectioned, and stained with hematoxylin and eosin, and scored for GVHD histopathology. (A) The top panels are representative sections from the skin of mice treated with DMSO, lovastatin and pravastatin. Skin shows moderate to severe changes consistent with GVHD with lymphoid infiltrates (arrow), epidermal and adnexal cell apoptosis in WT and pravastatin-treated mice. There were only mild changes noted in the skin of lovastatin-treated mice. The lower panels are representative sections from the liver. Perivascular lymphoid infilrates (arrows) within portal triads associated with bile duct damage were noted in the liver of WT and pravastatin treated mice but not in the lovastatin-treated mice. (B) The average score of skin and liver GVHD of each group. Results are mean and S.D. of total 4 mice. Asterisk represents data with p value less than 0.05 in t test.