TABLE 2.

Assay Endpoint (hormone) Quality Statistics

Hormone Short Name	Correlation of Maximum Fold Changea	Z′ (FOR)b	Z′ (PRO)c	SSMD (FOR)d	SSMD (PRO)e	BMADf	CR Cutoff (Fold-Change)g
11DCORT	0.82	0.76	0.88	15	−27	0.097	1.50
DOC	0.45	0.65	0.51	10	7	0.154	1.90
CORTISOL	0.78	0.67	0.83	11	−18	0.164	1.98
PROG	0.79	0	0.85	1	21	0.163	1.97
OHPROG	0.71	0.62	0	10	−2	0.150	1.87
OHPREG	0.64	0.81	0.77	20	3	0.119	1.64
ANDR	0.81	0.68	0.84	11	−19	0.127	1.70
TESTO	0.57	0.57	0.75	8	−13	0.172	2.05
ESTRONE	0.65	0.79	0.76	18	−14	0.135	1.75
ESTRADIOL	0.64	0.73	0.72	13	−11	0.173	2.05

^aCorrelation of log₂ fold-change was calculated by comparing maximum response achieved by the MTC tested in the MTC screening versus CR evaluation for 524 samples. Values presented are r² from Pearson correlations.

^bMedian Z-prime across all tested plates using forskolin (FOR) as the control.

^cMedian Z-prime across all tested plates using prochloraz (PRO) as the control.

^dMedian strictly standardized median difference (SSMD) across all tested plates using FOR as the control.

^eMedian SSMD across all tested plates using PRO as the control.

^fBaseline median absolute deviation (BMAD; presented as log₂ fold-change).

^gCR cutoff shown as a fold-change equating to 6× BMAD.