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. 2016 Mar 28;11(3):e0152007. doi: 10.1371/journal.pone.0152007

Fig 1. P450 enzymatic O-dealkylation activity assayed in Npc1+/+, Npc1+/-, and Npc1-/- mice at 3,6, and 9 weeks of age.

Fig 1

P450 O-dealkylation enzymatic activity of: MROD, methoxyresorufin-O-dealkylation; EROD, ethoxyresorufin-O-dealkylation; PROD, pentoxyresorufin-O-dealkylation, and BROD, benzoxyresorufin-O-dealkylation in Npc1+/+ (white), Npc1+/- (grey), and Npc1-/- (black) mice. Activity shown as percent of age-matched controls at 3 weeks (A), 6 weeks (B) and 9 weeks (C) of age. Data are presented as mean ± SEM, n = 6 (3 males and 3 females), * p—value < 0.05, ** p—value < 0.01, *** p—value < 0.001, **** p—value < 0.0001, calculated using two-tailed unpaired nonparametric Mann-Whitney test.