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. 2016 Mar 28;11(3):e0152007. doi: 10.1371/journal.pone.0152007

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Fig 8 — (A-D) Activity of CYP450 catalysed reactions in feline model of NPC1, shown as percent of age-matched controls. Age-matched NPC1^+/+ (white), NPC1^+/- (grey) and NPC1^-/- (black) cats were included in addition to HPBCD treated NPC1^-/- cats (striped). (E) CYP3A relative protein quantitation from western blot analysis was significantly lower in NPC1^+/-, and NPC1^-/- compared to age-matched NPC1^+/+ cats when analysed by densitometry. (F) Representative western blot analysis of CYP3A in the feline model of NPC1. Age-matched NPC1^+/+, NPC1^+/- and NPC1^-/- cats were included in addition to HPBCD treated NPC1^-/- cats. Methoxyresorufin-O-dealkylation (MROD); ethoxyresorufin-O-dealkylation (EROD); pentoxyresorufin-O-dealkylation (PROD); benzoxyresorufin-O-dealkylation (BROD). Data are presented as mean ± SEM, n = 3. Note due to small sample numbers all 3 ages (21, 38, and 59 weeks) HPBCD treated animals were combined for this figure. * p—value <0.05, ** p—value < 0.01, *** p—value < 0.001 calculated using one-way ANOVA test with Tukey’s post-hoc test.