Table 7. Regions of atrophy in the patient group with social attention scores less than the 20th percentile of healthy older controls.
| Brain Region | Peak MNI Coordinates | T-value (PFWE <0.05) |
||
|---|---|---|---|---|
|
| ||||
| x | y | z | ||
| Default Mode Area | ||||
| L MTL | -25 | 3 | -21 | 9.51 |
| R MTL | 25 | 4 | -18 | 8.78 |
| L PCC | -13 | -37 | 0 | 7.43 |
| dmPFC | 1 | 30 | 33 | 8.23 |
| Limbic Network | ||||
| L Amygdala | -22 | -11 | -13 | 9.07 |
| L Accumbens | -13 | 9 | -13 | 8.35 |
| R Accumbens | 10 | 7 | -13 | 8.04 |
| L mOFC | -22 | 7 | -18 | 9.48 |
| R vmPFC/mOFC | 10 | 9 | -18 | 8.55 |
| L aTL | -30 | 7 | -25 | 7.80 |
| R aTL | 27 | 7 | -24 | 7.79 |
| Salience / Task Control Network | ||||
| R inferior frontal gyrus | 24 | 9 | -16 | 9.01 |
| L AI | -27 | 9 | -16 | 8.82 |
| R AI | 25 | 9 | -16 | 8.78 |
| ACC | 1 | 28 | 31 | 8.21 |
| Mid Cingulate | 4 | 21 | 35 | 7.97 |
| RFO | 45 | 9 | -1 | 7.86 |
| R Putamen | 15 | 9 | -13 | 9.07 |
| L Putamen | -16 | 9 | -13 | 8.53 |
| Addition Regions | ||||
| Right Thalamus Proper | 15 | -32 | 1 | 8.51 |
| Left Thalamus Proper | -15 | -34 | -1 | 8.12 |
| L dlPFC | 49 | 15 | 28 | 7.89 |
| R dlPFC | -42 | 15 | 29 | 7.88 |
| L Precentral Gyrus | -43 | 6 | 31 | 7.66 |
| R Precentral Gyrus | 55 | -4 | 29 | 7.46 |
R = right; L = left; MTL=medial temporal lobe; PCC=posterior cingulate cortex; dmPFC=dorsomedial prefrontal cortex; mOFC=medial orbitofrontal cortex; vmPFC=ventromendial prefrontal cortex; aTL=anterior temporal lobe; AI=anterior insula; 10FC=lateral orbitofrontal cortex; ACC = anterior cingulate cortex; FO=frontal operculum; dlPFC = dorsolateral prefrontal cortex