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. 2016 Mar 28;11(3):e0151890. doi: 10.1371/journal.pone.0151890

Fig 1. Effects of cisplatin and metformin on cognitive function.

Fig 1

Mice received three cycles (5 daily injections of 2.3 mg/kg i.p followed by 5 days without injections) of cisplatin treatment with or without metformin (100 mg/kg i.p.). (A) Set up of novel object/place recognition test. (B) Effect of cisplatin and metformin on performance in the novel object/place recognition test. Data were analyzed by two-way ANOVA (interaction effect: Cisplatin×metformin, F(1,46) = 6.465, p<0.05) followed by LSD. (C) The total interaction time with novel and familiar object did not differ between groups. Data were analyzed by two-way ANOVA. (D) Set up of the social discrimination test. (E) Effect of cisplatin and metformin on performance in the social discrimination test. Data were analyzed by two-way ANOVA (Interaction: Cisplatin×metformin, F(1,44) = 4.42, p<0.05) followed by LSD. (F) The total interaction time during the test did not differ between groups. Data were analyzed by two-way ANOVA. (G) Effect of cisplatin and metformin on body weight (Time×Cisplatin, F(3,95) = 48, p<0.05). All data are expressed as mean±SEM. *, p<0.05. n = 10–14 per group.