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. 2016 Mar 28;12(3):e1005738. doi: 10.1371/journal.pgen.1005738

Fig 5. The bat-mouse BAR116 composite sequence displays a loss of tissue specificity in the limbs.

Fig 5

The M. lucifugus sequence (blue) was replaced with the mouse (red) PhastCons sequence encompassing the BAR element. While the M.lucifugus sequence drove consistent enhancer activity in the limbs at E12.5, both the mouse sequence and the synthesized bat-mouse BAR116 composite sequence failed to drive consistent enhancer activity, suggesting that the M. lucifugus BAR116 sequence is essential for limb enhancer expression.