Table 3. Pathway analysis of differentially expressed genes between low and high RFI sire groups by tissue, for pituitary (P), skeletal muscle (M), liver (L), adipose (A), and duodenum (D).
Top biofunctions by |Z-score| from IPA are provided, expressed as low relative to high RFI sire progeny group differences; all are significant (P<0.05). Functions associated with the immune system or fat deposition are grouped together, all other significant functions at the bottom.
| Diseases or Functions Annotation | P | M | L | A | D | Diseases or Functions Annotation | P | M | L | A | D |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Immune system | Fat deposition | ||||||||||
| activation of antigen presenting cells | 2.6 | differentiation of adipocytes | 2.4 | ||||||||
| immune response of antigen presenting cells | 2.0 | mass of adipose tissue | 2.2 | ||||||||
| inflammation of body region | 2.1 | concentration of triacylglycerol | -2.5 | ||||||||
| chemotaxis of granulocytes | 2.0 | synthesis of triacylglycerol | -2.4 | -2.6 | |||||||
| recruitment of granulocytes | 2.2 | quantity of diacylglycerol | -2.0 | ||||||||
| inflammation of large intestine | -2.7 | concentration of acylglycerol | -2.1 | ||||||||
| colitis | -2.7 | synthesis of acylglycerol | -2.2 | ||||||||
| activation of leukocytes | 2.3 | 2.7 | metabolism of membrane lipid derivative | -2.2 | |||||||
| immune response of leukocytes | 2.2 | concentration of 1,2-dipalmitoylphosphatidylcholine | -2.3 | -2.3 | -3.1 | ||||||
| recruitment of leukocytes | 2.7 | 2.8 | 2.8 | concentration of phosphatidylcholine | -2.2 | -2.1 | |||||
| activation of macrophages | 2.5 | beta-oxidation of fatty acid | -2.2 | ||||||||
| activation of mononuclear leukocytes | 2.3 | accumulation of lipid | -3.0 | -2.4 | |||||||
| cell movement of mononuclear leukocytes | 2.0 | binding of lipid | 2.0 | ||||||||
| response of mononuclear leukocytes | 2.6 | flux of lipid | 2.6 | 2.5 | |||||||
| activation of myeloid cells | 2.3 | transport of lipid | 2.8 | ||||||||
| response of myeloid cells | 2.4 | transport of cholesterol | 2.1 | ||||||||
| chemotaxis of neutrophils | 2.3 | fatty acid metabolism | 2.1 | ||||||||
| activation of phagocytes | 2.4 | transport of steroid | 2.2 | ||||||||
| immune response of phagocytes | 2.4 | steroid metabolism | -2.2 | ||||||||
| recruitment of phagocytes | 2.5 | 2.1 | 2.4 | concentration of hormone | -3.0 | ||||||
| response of phagocytes | 3.0 | 2.2 | binding of carbohydrate | 2.0 | 2.2 | ||||||
| viral infection | -2.3 | uptake of carbohydrate | 2.1 | ||||||||
| inflammatory response | 2.3 | 3.2 | insulin resistance | 2.1 | |||||||
| Other traits | |||||||||||
| morbidity or mortality | -2.2 | relaxation of artery | 2.7 | ||||||||
| necrosis | -2.5 | recruitment of blood cells | 2.4 | 2.6 | 2.6 | ||||||
| deposition of extracellular matrix | -2.2 | -2.2 | vasoconstriction | 2.0 | |||||||
| contractility of muscle | 2.2 | bleeding | -2.3 | ||||||||
| proliferation of muscle cells | 2.6 | function of cardiac muscle | 2.1 | ||||||||
| formation of fibrils | -2.2 | activation of cells | 2.3 | 2.0 | 2.2 | ||||||
| fibrogenesis | -2.0 | 2.2 | cell movement | 2.1 | 2.6 | ||||||
| injury of liver | 2.1 | engulfment of cells | 2.6 | ||||||||
| export of molecule | 2.3 | migration of cells | 2.1 | 2.8 | |||||||
| neurological signs | 2.2 | damage of endothelial cells | 2.0 | -2.2 | |||||||
| secretion of protein | 2.2 | damage of epithelial tissue | 2.5 | ||||||||
| soft tissue neoplasm | -2.1 | stimulation of epithelial cells | -2.1 | ||||||||