Increased drug exposure to RG7112 correlates with increased MDM2 mRNA levels. A, Scatter plot of the absolute change from baseline of MDM2 relative gene expression levels at day 10 pre-dose of cycle 1 in the blood vs AUCss (hr/ng/mL) of Stratum A patients. The circles represent individual patients. AUCss,area under curve at steady state; MDM2,murine double minute 2. B, Scatter plot of the absolute change from baseline of MDM2 relative gene expression levels at day 2 24 h post-dose in the blood vs MIC-1 of Stratum A patients. The circles represent individual patients. MIC-1,macrophage inhibitory cytokine-1; MDM2,murine double minute 2.