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. Author manuscript; available in PMC: 2016 Aug 15.
Published in final edited form as: Clin Cancer Res. 2015 Oct 12;22(4):868–876. doi: 10.1158/1078-0432.CCR-15-0481

Figure 2.

Figure 2

Increased drug exposure to RG7112 correlates with increased MDM2 mRNA levels. A, Scatter plot of the absolute change from baseline of MDM2 relative gene expression levels at day 10 pre-dose of cycle 1 in the blood vs AUCss (hr/ng/mL) of Stratum A patients. The circles represent individual patients. AUCss,area under curve at steady state; MDM2,murine double minute 2. B, Scatter plot of the absolute change from baseline of MDM2 relative gene expression levels at day 2 24 h post-dose in the blood vs MIC-1 of Stratum A patients. The circles represent individual patients. MIC-1,macrophage inhibitory cytokine-1; MDM2,murine double minute 2.