Table 2.

Influence of Increased Cumulative Exposure to Radiation and Chemotherapeutic Drugs on the ERR of Meningioma and Glioma/PNET

Exposures Included in the Model	Meningioma			Glioma/PNET
	Deviance	df	LRT P	Deviance	df	LRT P
Null model	127.54	92		81.79	59
Radiation, Gy*	50.83	91	< .001†	69.58	58	< .001†
Radiation* + alkylating agents mg/m2*	49.47	90	.245‡	69.55	57	.864‡
Radiation* + anthracyclines*	50.58	90	.621‡	68.89	57	.407‡
Radiation* + intrathecal methotrexate*	44.87	90	.015‡	68.81	57	.379‡
Radiation* + nonintrathecal antimetabolites*	49.22	90	.205‡	69.24	57	.561‡
Radiation* + epipodophyllotoxins*	49.69	90	.287‡	68.96	57	.429‡
Radiation* + vinca alkaloids*	48.12	90	.100‡	69.55	57	.854‡

NOTE. Radiation dosed in Gy; chemotherapeutic drugs dosed in milligrams per meter squared.

Abbreviations: ERR, excess relative risk; PNET, primitive neuroectodermal tumor; df, degrees of freedom; LRT, likelihood ratio test.

^*Fitted as a linear trend in continuous dose (model 1).

^†LRT P value relative to null model.

^‡LRT P value relative to model with radiation fitted as a linear trend in continuous dose.