Table 2.
List of immunoregulatorymolecules in the top 10% and 2-fold up-regulated in Tregs from filarial-infected subjects.
| Symbol | GenBank ID | Fold change | Biological functions |
|---|---|---|---|
| VEGFA | 7422 | 28.681 | May promote tumor growth and possess immunosuppressive properties |
| EREG | 2069 | 17.44 | May stimulate cell proliferation and/or angiogenesis |
| IL10 | 3586 | 11.167 | May function as an angiogenesis inhibitor |
| TNFSF15 | 9966 | 8.739 | May function as an angiogenesis inhibitor |
| PDGFA | 5154 | 6.225 | May promote tumor growth and possess immunosuppressive properties |
| CCL4 | 6351 | 6.134 | Recruit regulatory T cells to inflammatory sites |
| TNFSF4 | 7292 | 5.704 | Potential inhibitor of hypersensitivity |
| CXCL16 | 58191 | 5.574 | Recruit Tregs to tumor sites |
| IL29 | 100620067 | 3.094 | Contribute to Treg expansion by APCs |