Table 3.
Pulmonary function test and hemodynamic data stratified by the presence of right ventricular (RV) dilation on echocardiogram
| Variable | No RV dilation (n = 71) |
RV dilation (n = 56) |
Pa |
|---|---|---|---|
| Age, years | 60 (56–63) | 59 (53.5–63.0) | 0.64 |
| Male sex, no. (%) of patients | 47 (66.2) | 45 (80.4) | 0.08 |
| LVEF, % | 65 (60–70) | 65 (60–70) | 0.74 |
| FVC, % predicted, mean ± SD | 52.9 ± 14.9 | 50.3 ± 15.9 | 0.35 |
| FEV1, % predicted, mean ± SD | 57.7 ± 15.5 | 54.9 ± 17.3 | 0.34 |
| TLC, % predicted | 58 (51–64) (n = 69) | 57 (49–63.5) (n = 52) | 0.41 |
| DLCO, mL/min/mmHg | 9.2 (7.1–13.4) (n = 58) | 9.5 (7.1–11.5) (n = 44) | 0.42 |
| PASP, mmHg | 34 (29–41) | 40 (34–49) | 0.001 |
| Mean PAP, mmHg | 22 (17–26) | 25.5 (20.5–31.5) | 0.002 |
| PVR, Wood units | 3 (2.2–3.9) (n = 70) | 3.4 (2.8–5.3) (n = 53) | 0.001 |
| PCWP, mmHg | 10 (8–13) (n = 70) | 8.5 (6.5–14.0) | 0.61 |
| Cardiac output, L/min, mean ± SD | 5.6 ± 1.3 (n = 70) | 5.6 ± 1.4 (n = 53) | 0.88 |
| Cardiac index, L/min/m2, mean ± SD | 2.9 ± 0.5 (n = 70) | 2.8 ± 0.6 (n = 53) | 0.60 |
| Abnormal RV function, no. (%) of patients | 4 (5.6) | 29 (52.7) (n = 55) | <0.001 |
| Six-minute walk distance, m, mean ± SD | 411.4 ± 116.3 | 345.6 ± 128.4 | 0.003 |
| Nadir oxygen saturation, %, mean ± SD | 88.9 ± 5.8 | 87.3 ± 4.1 | 0.06 |
Data are median (interquartile range) unless otherwise indicated. DLCO: diffusing capacity of the lung for carbon monoxide; FEV1: forced expiratory volume in 1 second; FVC: forced vital capacity; LVEF: left ventricular ejection fraction; PAP: pulmonary artery pressure; PASP: pulmonary artery systolic pressure; PCWP: pulmonary capillary wedge pressure; PVR: pulmonary vascular resistance; SD: standard deviation; TLC: total lung capacity.
Fisher exact test or χ2 test for categorical variables; Student t test with equal variance for normally distributed continuous variables; Mann-Whitney U test for nonnormally distributed continuous variables.