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. Author manuscript; available in PMC: 2016 Mar 28.
Published in final edited form as: Hepatology. 2014 May 19;60(2):554–564. doi: 10.1002/hep.27153

Fig. 1.

Fig. 1

miR-24 is highly induced in livers of HFD-treated mice and human hepatocytes treated with fatty acid. To identify the function of highly and specifically expressed miRNAs in hepatocytes in NAFLD, we determined the expression levels of the top 10 miRNAs in the livers of mice maintained on HFD for 2 months using Taqman microRNA Assay. (A) HFD treatment led to higher levels of miR-24 in livers of mice. (B,C) Oleate treatment increased lipid accumulation and (D) expression of miR-24 in primary human hepatocytes. The lipid content in the cultured hepatocytes was determined fluorimetrically using Nile Red, which has been shown to selectively stain intracellular lipid droplets. Data represent mean ± SEM. *P < 0.05.