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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Nanomedicine. 2015 Nov 14;12(3):655–664. doi: 10.1016/j.nano.2015.10.012

Figure 3. Effect of Pgp inhibition on Dox accumulation in MDR and sensitive cancer cells.

Figure 3

The accumulation of free Dox or exoDox in MDCKMDR1 and MDCKWT cells was studied in cell lysates. The Dox incorporation into exosomes significantly increased accumulation in sensitive and resistant cells, while no effect of verapamil on exoDOX accumulation was found in both cell lines.