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. 2016 Mar 29;10:77. doi: 10.3389/fncel.2016.00077

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Copyright © 2016 Bálint, Liposits and Farkas.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The selective ERα agonist and G protein-coupled estrogen receptor (GPR30) agonist exert no effects on the mPSCs in GnRH neurons of the metestrous female mice. (A) The selective ERα agonist PPT (10 pM, 10 min) was unable to modify the frequency of mPSCs in the recorded GnRH neurons. (B) Similarly, the GPR30 receptor agonist G1 (10 pM; 10 min) did not modify the frequency of the mPSCs. Arrowhead shows the onset of drug administration. Individual events of mPSC show no change in waveform properties of the treated phase (lower insets) compared to the control phase (upper insets) in each mPSC measurements. Cumulative probability plots of the treatments show no change in interevent intervals or amplitudes.