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. 2016 Mar 29;10:77. doi: 10.3389/fncel.2016.00077

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Copyright © 2016 Bálint, Liposits and Farkas.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bar graph summarizing the percentage changes in the frequency and the amplitude of the mPSCs resulting from E2 treatment in the presence of Faslodex, AM251 and THL. E2 significantly decreased the frequency of mPSCs. Inhibition of this effect could be achieved with antagonizing the ERs by Faslodex. Effect of E2 was eliminated by the pretreatment with CB1 inverse agonist AM251 or the intracellularly applied 2-AG endocannabinoid synthesis blocker THL. The amplitude of the mPSCs did not change in any of the treatments. *p < 0.05 as compared to the control; **p < 0.05 as compared to the change evoked by E2 treatment.