TABLE 2.
Evaluation of qPCR assays for BV diagnosis based upon nonquantitative detection of organisms
| Organism | Sensitivity (%) (95% CIa) | Specificity (%) (95% CI) | Likelihood ratio (95% CI) |
|---|---|---|---|
| G. vaginalis | 98.3 (95.0–99.6) | 42.5 (35.8–49.5) | 1.71 (1.52–1.92) |
| A. vaginae | 93.6 (88.8–96.7) | 57.5 (50.6–64.2) | 2.20 (1.87–2.58) |
| BVAB2 | 80.1 (73.3–85.8) | 82.2 (76.5–87.1) | 4.32 (3.23–5.76) |
| Megasphaera phylotype 1 | 68.4 (60.9–75.3) | 98.1 (95.3–99.5) | 36.6 (13.8–97.2) |
| Megasphaera phylotype 2 | 31.0 (24.2–38.5) | 100 (98.3–100) | Infinity |
| Megasphaera phylotype 1 or phylotype 2 | 80.7 (74.0–86.3) | 98.1 (95.3–99.4) | 43.2 (16.3–114) |
| L. iners | 94.2 (89.5–97.2) | 17.8 (12.9–23.6) | 1.14 (1.06–1.23) |
| Absence of L. crispatus | 82.5 (75.9–87.8) | 40.7 (34.0–47.6) | 2.32 (1.61–3.33) |
| Absence of L. gasseri | 94.2 (89.5–97.2) | 14.5 (10.1–19.9) | 1.10 (1.03–1.18) |
| Absence of L. jensenii | 90.6 (85.3–94.6) | 39.3 (32.7–46.1) | 1.49 (1.33–1.68) |
| Absence of L. crispatus, L. gasseri, and L. jensenii | 70.1 (63.5–76.1) | 73.7 (66.4–80.1) | 2.46 (1.97–3.08) |
a
CI, confidence interval.