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. 2016 Mar 25;54(4):1117–1126. doi: 10.1128/JCM.02700-15

TABLE 3.

Spearman correlation between CWD-positive animals and clinical variablesa

Correlation Obex RLN RAMALT
NB RT-QuIC
132MM 132ML Obex score of:
IHC analysis RT-QuIC KSU RML 0 1 2 3 4
Positiveb 0.86 (<0.001)c 0.95 (<0.001) 0.83 (<0.001) 0.83 (<0.001) 0.50 (<0.001) 0.48 (<0.001) 0.26 (0.19) −0.26 (0.19) −0.86 (<0.001) 0.24 (0.25) 0.17 (1.00) 0.40 (<0.001) 0.59 (<0.001)
RAMALT IHC analysis 0.92 (<0.001) 0.87 (<0.001) 1.0 (<0.001) 0.96 (<0.001) 0.60 (<0.001) 0.58 (<0.001) 0.30 (0.04) −0.30 (0.04) −0.92 (<0.001) −0.01 (1.0) 0.21 (0.69) 0.48 (<0.001) 0.71 (<0.001)
132MM 0.32 (<0.001) 0.23 (0.01) 0.30 (<0.001) 0.30 (<0.001) 0.21 (0.02) 0.20 (0.03) 1.0 (<0.001) −1.0 (<0.001) −0.32 (0.02) −0.01 (1.0) 0.07 (1.0) 0.17 (1.0) 0.25 (0.24)
132ML −0.32 (<0.001) −0.23 (0.01) −0.30 (<0.001) −0.30 (<0.001) −0.21 (0.02) −0.20 (0.03) −1.0 (<0.001) 1.0 (<0.001) 0.32 (0.02) 0.01 (1.0) −0.07 (1.0) −0.17 (1.0) −0.25 (0.24)
a

Including postmortem IHC results, antemortem IHC and RT-QuIC analyses of RAMALT and nasal brushings (NB), the PRNP 132 genotype, and the stage of clinical disease as assessed by obex score.

b

Correlation applies to tissue correlated with either an obex or an RLN sample that was positive for CWD by IHC analysis.

c

Shown are correlations (P values).