. Author manuscript; available in PMC: 2016 Apr 1.

Published in final edited form as: Orthod Craniofac Res. 2015 Apr;18(Suppl 1):71–82. doi: 10.1111/ocr.12078

Table 3.

Final linear regression analysis of key variables influencing EARR

Variables	p-value	Layered Bonferroni corrected significant alpha
Length of time in treatment (years)	<0.0001^*	0.006
P2RX7, rs208294 {CC&CT vs. TT}	0.0028^*	0.006
Upper 1st Premolars were extracted or missing	0.0469	0.007
IL1β, rs1143634 {AA&GA vs. GG}	0.0533	0.008
Change in FMA	0.0591	0.01
P2RX7, rs1718119 {AA&GG vs. GA}	0.0813	0.01
Change in Ur-pvt	0.0908	0.02
CASP1/ICE, rs530537 {TT vs. CC&TC}	0.1527	0.03
P2RX7, rs208294 {CC vs. CT}	0.1564	0.05

Statistically significant compared to alpha corrected by layered Bonferroni procedure; Extraction of second premolars was not included in the analysis. The factors summarized in the table explain 25.13% of the variation observed in this sample.