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. 2016 Apr;147(4):337–351. doi: 10.1085/jgp.201511551

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© 2016 Li et al.

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Figure 3. — Identification of amino acids within the TM segment important for the BKγ modulatory function. (A and B) Voltage dependence of BK channel activation in the presence of γ1/γ4 chimeras whose main bodies were from γ1 and whose TM segment and linker regions were fully or partly from γ4. The chimera in which the single residue F273 (γ1) remained unchanged is indicated with a superscript. (C and D) Voltage dependence of BK channel activation in the presence of different BKγ subunits with a Phe↔Ser mutation at the 12th position of their TM segments. (E and F) Voltage dependence of BK channel activation in the presence of single or double mutations at or near the 12th position (Phe273) of the BKγ1 TM segment. For comparison, the γ1-F273S mutant is also shown with dotted lines in E and F. Error bars represent ±SEM.