Tumor hypoxic condition |
Increased drug efflux and decreased drug uptake |
Increased cellular production of cellular antioxidants |
Inactivation of apoptosis |
Activation of certain proto-oncogenes, and stromal interactions |
Increased drug metabolism and drug compartmentalization |
Amplification of DNA repair genes |
Increase in the repair of DNA damage |
Cancer stem cells as contributors to radioresistance |
Increased or altered the drug targets |
Survival signals favoured by transcription factors |
Survival signals favoured by transcription factors |