Table A2.
Innate Lymphoid Cells | T Cells | ||||||
---|---|---|---|---|---|---|---|
Inducing Cytokines | Lineage-Specific Transcription Factor | Secreted Cytokines | Inducing Cytokines | Lineage-Specific Transcription Factor | Secreted Cytokines | ||
ILC1 | IL-12, IL-15, IL-18 | Tbet | IFN-γ TNF-α |
TH1 | IL-12 IFN-γ |
Tbet | IFN-γ IL-2 |
ILC2 | IL-25, IL-33, TSLP | Gata3, RORα | IL-4, IL-5, IL-13, amphiregulin | TH2 | IL-4 | Gata3 | IL-4, IL-5, IL-9, IL-13 |
ILC3 | IL-1β, IL-23 | RORγt, Ahr | IL-17, IL-22, LT, GM-CSF | TH17 | TGF-β IL1-β, IL-6, IL-21, IL-23 |
RORγt | IL-17 IL-6 |
NK | IL-12, IL-15, IL-18 | Eomes | IFN-γ | CTL | IL-2, IFN-γ |
Ahr: Arylhydrocarbon receptor; CTL: Cytotoxic T lymphocyte; ILC: innate lymphoid cell; NK: natural killer cell; TH: T helper cell.