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. 2016 Mar 17;5(1):31. doi: 10.3390/pathogens5010031

Table A2.

Parallels in differentiation and function of innate lymphoid cells (ILCs) and T cells.

Innate Lymphoid Cells T Cells
Inducing Cytokines Lineage-Specific Transcription Factor Secreted Cytokines Inducing Cytokines Lineage-Specific Transcription Factor Secreted Cytokines
ILC1 IL-12, IL-15, IL-18 Tbet IFN-γ
TNF-α
TH1 IL-12
IFN-γ
Tbet IFN-γ
IL-2
ILC2 IL-25, IL-33, TSLP Gata3, RORα IL-4, IL-5, IL-13, amphiregulin TH2 IL-4 Gata3 IL-4,
IL-5, IL-9, IL-13
ILC3 IL-1β, IL-23 RORγt, Ahr IL-17, IL-22, LT, GM-CSF TH17 TGF-β
IL1-β, IL-6, IL-21, IL-23
RORγt IL-17
IL-6
NK IL-12, IL-15, IL-18 Eomes IFN-γ CTL IL-2, IFN-γ

Ahr: Arylhydrocarbon receptor; CTL: Cytotoxic T lymphocyte; ILC: innate lymphoid cell; NK: natural killer cell; TH: T helper cell.