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. 2016 Mar 29;7:79. doi: 10.3389/fphar.2016.00079

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Copyright © 2016 Fan, Zhang, Wu, Guo, Su, Liu and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of Ani on mortality and serum biochemicals in rats with crush syndrome. Ani (20 mg/kg, i.p.) was administrated 30 min before (Ani-pre) or 1 h after (Ani-post) decompression. Blood samples were collected at 6 h after decompression. Ani prolonged survival time after decompression (A). Serum CK, CK-MB, BUN, Scr, and K⁺ levels were significantly reduced by Ani (B–F). Ani had no effect on serum Na⁺ and Cl^- levels (G,H). N = 20 per group. ^∗P < 0.05, ^∗∗P < 0.01, ^∗∗∗P < 0.001 vs. control. Power = 0.90, 1.00, 1.00, 1.00, 1.00, 1.00, 0.11, and 0.13 for (A–H) respectively.