Skip to main content
. 2016 Mar 29;7:79. doi: 10.3389/fphar.2016.00079

FIGURE 4.

FIGURE 4

Involvement of α7nAChR in the effect of Ani on insulin sensitivity in mice with crush syndrome. Ani (28 mg/kg) or PNU (4 mg/kg) was administrated i.p. at 30 min before decompression in mice with crush syndrome, and MLA (10 mg/kg, i.p.) was given 30 min earlier. Blood samples were collected at 6 h after decompression. Ani and PNU reduced serum insulin (A) and glucose (C) and HOMA-IR index (E), and elevated QUICKI (G) in C57BL/6 mice after decompression, and MLA significantly counteracted the effects of Ani. Ani reduced serum insulin (B) and glucose (D) and HOMA-IR (F) index, and elevated QUICKI (H) in WT mice for α7nAChR after decompression, which was abolished in α7-/- mice. N = 6 per group. ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001 vs. control. #P < 0.05, ##P < 0.01, ###P < 0.001 vs. Ani. Power = 1.00, 1.00, 1.00, 0.91, 1.00, 1.00, 1.00, and 1.00 for (A–H) respectively.