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. 2015 Dec 23;6(1):1. doi: 10.3390/life6010001

Figure 1.

Figure 1

Ribozyme-mediated RNA modification: (A) Introduction of a modification (red circle) catalyzed by a catalytic motif within the RNA to be modified [44,45]. Note that self-modification can occur also 5′- or 3′-terminal (as for aminoacylation [13,14,15,16,17,18,25,41]); (B) Ribozyme mediated RNA modification of the 5′- or 3′-terminus, respectively, using modified building blocks (blue rectangle) such as nucleotide or nucleobase derivatives [57,58,59,65]; (C) Ribozyme mediated insertion of a short modified oligonucleotide into the target RNA [66]; (D) Ribozyme mediated replacement of a short RNA segment for a modified oligonucleotide [67,68,69,70].