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. 2016 Mar 10;8(3):78. doi: 10.3390/v8030078

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Antigen capsid-incorporation vector elicits an in vivo T. cruzi humoral immune response. (A) Study design: C57BL/6 mice (n = 7) were primed and boosted with 3 × 10¹⁰ VP of Ad5, Ad5-pIX-gp83, Ad5-pIX-ASP-C, Ad48, Ad48-pIX-gp83, or Ad48-pIX-gp83. Two weeks after the last immunization serum was collected for ELISA binding assays. Either 10 μM of gp83 peptide or the ASP-C peptide was bound to ELISA plates; (B) Post-prime and post-boost serum from mice immunized with the T. cruzi gp83 modified vectors; (C) Post-prime and post-boost serum from mice immunized with the T. cruzi ASP-C pIX-modified vectors. The amount of anti-gp83 and anti-ASP-C antibodies in the sera was expressed as the mean ± SEM. (*) = p ≤ 0.05.

Antigen capsid-incorporation vector elicits an in vivo T. cruzi humoral immune response. (A) Study design: C57BL/6 mice (n = 7) were primed and boosted with 3 × 10¹⁰ VP of Ad5, Ad5-pIX-gp83, Ad5-pIX-ASP-C, Ad48, Ad48-pIX-gp83, or Ad48-pIX-gp83. Two weeks after the last immunization serum was collected for ELISA binding assays. Either 10 μM of gp83 peptide or the ASP-C peptide was bound to ELISA plates; (B) Post-prime and post-boost serum from mice immunized with the T. cruzi gp83 modified vectors; (C) Post-prime and post-boost serum from mice immunized with the T. cruzi ASP-C pIX-modified vectors. The amount of anti-gp83 and anti-ASP-C antibodies in the sera was expressed as the mean ± SEM. (*) = p ≤ 0.05.