Table I.
Characteristics of patients reported to have sarcoidosis after allogeneic HSCT
| Study | Heyll2 | Sundar3 | Tauro4 | Morita5 | Bhagat6 | Gooneratne7 | Pukiat8 | Kushima9 | Current case | |
|---|---|---|---|---|---|---|---|---|---|---|
| Age (y) & Sex | 34 M | 37 F | 36 F | 55 F | 51 F | 45 F | 51 M | 47 M | 64 F | 58 F |
| Type of HSCT, donor | Allo, sibling | Allo, sibling | Allo, sibling | Allo, UD | Allo | Allo, UD | Allo, UD | Allo, UD | Allo, UD | Allo, sibling |
| Family history of sarcoidosis | +Donor | +Donor | +Donor & +Patient | None | None | None | None | None | None | None |
| Donor diagnosed with sarcoid before or after the HSCT? (at the time of case publication) | Yes, before the HSCT | Yes after the HSCT (Lymph node biopsies with noncaseating granulomas) | Yes, before the HSCT (sarcoidosis of the liver) | Unknown | Unknown | No | No | No | Unknown | No signs or symptoms of sarcoidosis to date (31 months posttransplant) |
| Underlying disease | NHL | B cell lymphoma | CML | FL | CML | MDS | MDS | CMML | ATL | MF |
| HLA | A1, A2, B8, B51, DR4, DR4 | A(1,26), B(8,49), Cw(7,-), DRb1*03011, DRb1*1302 | A-24(9), B-8 52(5), C-7 16; DR-17(3) 18(3) DQ-2 4 DP- |
Donor had one locus mismatch HLA phenotype & genotype (DRB1 locus) | Unknown | Unknown | Unknown | A*0101, A*2501, B*0801, B*1801, DRB1*0301, DRB1*1501, DQB1*0201, DQB1*0602 | Unknown | A*0301, B*0702, B*5501, C*0702, C*0304, DRB1*1301, DRB1*1501, DQB1*0602 |
| Post-HSCT period (mo) | 3 | 18 | 21 | 6 | 6 | 12 | 20 | 22 | 16 | 27 |
| Organs confirmed to have noncaseating granulomatous changes on biopsy | Lung & liver | Lung, (skin biopsy not done) | Bone marrow | Mediastinal lymph nodes, pleura, and a piece of lung | Lung | Liver, Skin: non-caseating granulomas |
Liver | Lymph nodes, Skin: poorly defined granulomatous inflammation in the deep dermis |
Lung, mediastinal lymph nodes, Subcutaneous mass in left upper arm: noncaseating granulomas |
Lung, skin: noncaseating granulomas |
| Clinically evident cutaneous lesions reported | No | Petechial rash owing to chronic GVHD over lower extremities; skin bx not done |
No | No | No | Purple-brown firm skin lesions on limbs, upper back, right cheek | No | Papular rash (cutaneous chronic GVHD), indurated erythematous plaque (granulomatous) |
Subcutaneous mass in left upper arm | Red papules with minimal scale on forearms and trunk; White firm atrophic patches inferior to bilateral breasts |
Allo, Allogeneic; ATL, adult T-cell leukemia; CML, chronic myeloid leukemia; CMML, chronic myelomonocytic leukemia; FL, follicular lymphoma; MDS, myelodysplastic syndrome; MF, myelofibrosis; NHL, non-Hodgkin's lymphoma; UD, unrelated donor.