Fig. 4.

Effects of AMPK activators on the changes of p130Cas protein induced by Ang II. Ang II suppresses p130Cas protein significantly in a time-dependent manner. (A) Compound C further exaggerates the reduced p130Cas protein significantly (all P < 0.01, not denoted) at all experiment times. (B) Concerning the concentration of 10^-7 M Ang II at 24 hours, Ang II suppresses p130Cas protein significantly, which is also reversed by AICAR and metformin. Compound C further aggravates the changes of p130Cas. Data on the densitometric analysis of p130Cas/β-tubulin ratio are expressed as mean ± SD (n = 3). Control (100%); the value of no Ang II conditions.

*P < 0.05 and ^† P < 0.01 vs. control. ^‡ P < 0.05 and ^§ P < 0.01 vs. Ang II-treated groups.