Figure 1.

Diabetic families who have probands with IPF-1 mutations. Shown is mutation status within families with either a MODY proband diagnosed before 25 years of age (MY54 and MY99) or type 2 diabetes diagnosed at 35–70 years of age (4/22, 4/25, 4/55, 4/116, 4/127, 4/159, and 4/185). Squares representing diabetic subjects are completely filled, and squares representing patients with impaired glucose tolerance are half-filled. Family number and mutation designation is given above the pedigree. Individual mutation status is given: N = normal, M = mutation. For affected subjects, age at diagnosis, followed by treatment requirement (OHA = oral hypoglycemic agents; Ins = insulin), is given. For unaffected subjects, age at testing, followed by either 2-hour glucose value after oral glucose load or by fasting blood glucose value (FBG) or not tested (NT), is given.