TABLE 1.

Summary of results from different studies on TAp73's role in angiogenesis^a

Model system	Reference	Effect on tumor size	Effect on angiogenesis	Vegf-A/angiogenic gene expression		Conditions for gene silencing/inducible overexpression	p53 status
				In vivo	In vitro
Tumor models
TPA-DMBA chemical carcinogenesis in TAp73−/− mice	11	Larger tumors	Increased
Eμ-Myc transgenic mouse lymphomagenesis in TAp73−/− mice	12		Increased
E1a/Ras-transformed TAp73−/− MEFs in nude/Scid mice	12	Larger tumors	Increased	Increased	Increased
	13	Smaller tumors	Decreased		Decreased		Wild type
Xenograft model in nude mice with H1299 cells with TAp73 silencing	11	Larger tumors	Increased	Increased	Increasedb	Stable	Null
	13				Decreased	Transient	Null
Xenograft model in nude/Scid mice with H1299/SAOS2 cells with inducible TAp73 expression	11	Smaller tumors (SAOS2)			Decreased (H1299)	Long term, from initiation of tumors (5 weeks)	Null
	13	No difference (H1299 and SAOS2)	Increased		Increased (SAOS2)	Transient (6 days after tumor establishment)	Null
Other models
Aorta ring from TAp73−/− mice	11		Increased
Retina and iPSC from total p73−/− mice and MSC with p73DD	15		Decreased in all cases	Decreased in retina	Decreased in MSC
HUVEC cells with p73DD overexpression or total p73 or TAp73 silencing	15		Decreased (p73DD and total p73 silenced) and no difference (TAp73 silenced)		Decreased in all cases	Transient	Wild type

^aData from articles that demonstrate an inhibitory role for TAp73 in angiogenesis are in boldface. Data from reports on TAp73 as a positive regulator of angiogenesis are in lightface. A cell without data represents data not provided in the article.

^bFrom reference 12.