FIG 1.

Membrane insertion profile of the (non)palmitoylated Drd3 C terminus. (A) The binding site of GIPC1 to the C-terminal domain of Drd3 contains a putative palmitoylation site. (B) Average backbone insertion values (means ± SEM of 8 replicates) for (non)palmitoylated Drd3 C termini were calculated as described in Materials and Methods. The data show the level of the phosphorous atom of lipids at the water-membrane interface. The model predicted that the Drd3 C terminus is inserted more deeply in the membrane environment when palmitoylated (paired t test; *, P < 0.0001).