FIG 6.

CD8^dim CD38⁺ CD27⁻ T cell population demonstrates a less efficient ability to inhibit viral replication in vitro and is associated with higher viral loads in vivo. (A) Sorting strategy for CD8^bright and CD8^dim cells. (B) Differences in viral inhibition between CD8^bright and CD8^dim T cells. (C) CD8^dim CD38⁺ CD27⁻ T cell frequency correlates positively with contemporaneous viral loads an average of 7 days after peak viral load and (D) negatively correlates with contemporaneous CD4⁺ T cell count. (E) Maximum CD8^dim CD38⁺ CD27⁻ T cell frequency was predictive of HIV set point using linear regression after the removal of two potential outliers. (F) CD8^dim CD38⁺ CD27⁻ T cell frequency an average of 7 days after peak viral load correlates directly with set point activation of CD4⁺ T cells (CD38⁺ HLADR⁺).