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Characterization of recombinant gp120s for ELISA binding with CD4-Ig (top) and VRC01 (middle) and for neutralization competition with VRC01 (bottom). The gp120 sequences were based on JR-FL, Yu2, and AC10.29, as indicated. Each strain was tested as the WT or with a point mutation (D368R or W479A). (Bottom) For neutralization competition assays, the D368R and W479A gp120 mutants were tested at 25 μg/ml to adsorb VRC01 neutralizing activity against the indicated gp120-matched strains.
