TABLE 3.
Neutralization IC50 titers of isolated human and macaque gp120-specific MAbs
| MAb ID | Epitope | Neutralization IC50 (μg/ml)a |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Tier 1 |
Tier 2 |
||||||||||
| HXB2 | SF162 | BaL.01 | JR-FL | Yu2 | AC10.29 | REJO.67 | AD358_m2 | SHIVSF162P3Nclone 8 | SHIVSF162P3Nclone 10 | ||
| AD358_n1 | CD4bs | 0.22 | 0.10 | 50 | 0.19 | 5.3 | >50 | 9.1 | 3.7 | ||
| AD358_n1.2 | CD4bs | 0.05 | 0.16 | 0.26 | 0.34 | 8.6 | >50 | 1.5 | 3.0 | ||
| AD358_n1.6 | CD4bs | 15.0 | >50 | >50 | 2.4 | >50 | >50 | 1.8 | 0.91 | ||
| AD358_n2 | CD4bs | 0.28 | 0.06 | 0.05 | 0.17 | >50 | >50 | 31.0 | 6.3 | ||
| AD358_n3 | CD4bs | >50 | 2.7 | >50 | 50.0 | >50 | >50 | 0.69 | 4.7 | ||
| AD358_b4 | CD4bs | 0.41 | 1.4 | >50 | >50 | >50 | >50 | >50 | >50 | ||
| AD358_b5 | CD4bs | 0.05 | 0.21 | 7.0 | >50 | ND | ND | ND | >50 | ||
| AD358_b6 | CD4bs | 0.06 | 0.38 | >50 | >50 | ND | ND | ND | >50 | ||
| AD358_b7 | V3 loop | >50 | 0.002 | 0.11 | >50 | ND | ND | ND | >50 | ||
| GB40_b1 | V3 loop | >50 | 0.03 | 0.72 | 50.0 | >50 | >50 | >50 | >50 | ||
| GB40_b2 | V3 loop | 0.72 | 0.01 | 0.85 | 50.0 | >50 | >50 | >50 | >50 | ||
| GB40_b3 | V3 loop | >50 | 16.4 | 15.5 | >50 | >50 | >50 | >50 | >50 | ||
| GB40_b4 | V3 loop | >50 | 0.02 | 0.34 | 45.0 | >50 | >50 | >50 | >50 | ||
| GB40_b5 | V3 loop | 0.03 | 0.08 | 2.4 | >50 | >50 | >50 | >50 | >50 | ||
| GB40_b6 | V3 loop | 11.5 | 0.23 | 2.6 | 50.0 | >50 | >50 | >50 | >50 | ||
| GB40_b7 | V3 loop | 1.9 | 0.05 | 7.9 | >50 | >50 | >50 | >50 | >50 | ||
| GB40_b8 | V3 loop | >50 | 0.09 | 1.7 | >50 | >50 | >50 | >50 | >50 | ||
| GB40_b9 | V3 stem | >50 | 0.04 | 1.1 | 45.0 | >50 | >50 | >50 | >50 | ||
| GB40_b10 | Inner domain | >50 | >50 | >50 | >50 | >50 | >50 | >50 | >50 | ||
| GB40_b11 | C5 | >50 | >50 | >50 | 45.0 | >50 | >50 | >50 | >50 | ||
| GB40_b12 | C5 | >50 | >50 | >50 | >50 | >50 | >50 | >50 | >50 | ||
| GB40_b13 | C5 | >50 | >50 | >50 | >50 | >50 | >50 | >50 | >50 | ||
a
ND, not done.