FIG 1.

Low particle multiplicity is sufficient to induce an antiviral response. Virus stocks of SeV or HCMV were diluted, and their properties were measured using tunable resistive pulse sensing. The size distribution (A) and particle concentration, with standard error (B), of virus stocks were calculated by comparing the amplitude and frequency of pore obstructions to calibration beads of known size and concentration. PFU were converted to total virus particles when determining how many particles are sufficient to induce an IFN-independent response.