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Working model of EBNA3 binding and gene regulation. (Top) At RBPJ sites, EBNA3 binding limits EBNA2 access, resulting in cell gene repression. The specific sites bound by each EBNA3 are determined by interactions with other cell transcription factors, including IRF4 in the case of EBNA3C, as depicted. (Bottom) At non-RBPJ sites, EBNA3 binding would not generally affect EBNA2 binding and produces activation or repression in a context-dependent manner.
