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Heat stability of mutant viruses derived from the H5HA-N224K+Q226L/CA04 virus. After the third heat treatment, we performed plaque assays in AX4 cells, randomly selected 20 plaques (P1 to P20), amplified them in AX4 cells, and determined their virus titers (A) and HA titers (B) after treatment at 50°C for the indicated time periods. The mutations detected in the HA proteins of these viruses are presented in Tables 1 and 2.
