TABLE 2.
HA-stabilizing mutations listed by plaque number
| Virus plaquea | Mutation(s) |
|---|---|
| L1 | A218V |
| L53 | L418I |
| L6 | R397M |
| L133 | I29M |
| L153 | D101N, M230V |
| L17 | L418I |
| L18 | R397M |
| L19 | L427I |
| P11 | S221P |
| P32,3 | D95*G, S221P |
| P41 | S221P, R456K |
| P52,3 | S221P |
| P81 | S221P |
| P92 | S221P |
| P11 | L427I |
| P14 | R397M |
| P15 | L418I |
| P18 | R397M |
| P193 | I29M, S221P, M431L |
| P203 | S221P |
a
L1 to L20, plaques derived from virus library; P1 to P20, plaques derived from parental sample. Superscript numbers: 1, sequencing revealed reversion from L226 to Q226; 2, sequencing revealed both L226 and Q226; 3, sequencing revealed both the wild-type amino acid and the amino acid identified after heat treatment (for example, sequence analysis of plaque P19 revealed both isoleucine and methionine at position 29).