FIG 4.

Analysis of genes at which Pol II occupancy changed less than 2-fold after HSV-1 infection. (A) Occupancy of Pol II around the TSSs and 3′ ends for the 61 genes whose rpk values across their bodies changed less than 2-fold after HSV-1 infection. Normalized sequence tags were histogrammed in 10-bp bins for 2 kb centered on the TSS or in 100-bp bins for 4 kb centered on the 3′ end. (B) Representative ChIP-seq data for the Calr gene showing that promoter-proximal occupancy of Pol II decreased significantly after HSV-1 infection while Pol II occupancy across the body of the gene changed less than 2-fold. The mock infection data are shown with two different y axes. The graphs were created from the UCSC Genome Browser.