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SIVmac239, SIVsmE543-3, and SHIV-AD8 are primarily CCR5 dependent in RM PBMC. PHA-stimulated RM PBMC were infected with SIVagmVer90 (A), SIVmac239 (B), SIVsmE543-3 (C), or SHIV-AD8 (D) in the absence (black) or presence (red) of maraviroc (15 μM). Viral replication kinetics were determined by measuring the RT activity in culture supernatants over a 3-week period. Graphs depict mean RT activities ± SD for representative experiments (n = 3).
